The breakthrough is set to be warmly received by the medical and biotechnology communities where researchers will be able to utilise a new hybrid method, which combines the best of new and old code cracking methods for "fingerprinting" the genetic basis of life. The newer method, which has emerged in the past year, uses real-time, light-based observations of gene synthesis to reveal genomic information. It produces genomic information up 100 times faster than the old technology.

Using the genomes of six ocean bacteria, US and Austrian scientists evaluated the utility and cost effectiveness of the old and new methods to show that a hybrid method was better than either method on its own.

They found that combining the advantages of the two sequencing methods in a hybrid approach produced better quality genomic information.

The team found that the traditional method known as 'Sanger' sequencing worked best at sequencing large segments of the genomes, while the newer method known as '454 pyrosequencing' was more adept at sequencing smaller, more difficult sections, such as unclonable regions and gaps induced by secondary structures.

The hybrid sequencing approach enabled the scientists to more easily close sequencing gaps between genome fragments compared with previous techniques.

The researchers suggest that the hybrid technique will become the preferred method for sequencing small microbial genomes, as the Sanger method is more capable of sequencing larger segments of DNA.

"The new hybrid approach has generated exceptional results for several, marine microbes and we hope that our findings will kick-start other genome projects that were previously constraint by economic considerations," said Dr Torsten Thomas, a study co-author and senior research fellow at the University of New South Wales.

"Cracking the entire, genetic code of an organism is expensive and until recently has relied on technology that involves a physical separation of gene fragments," added Thomas.

Scientists from the US-based J. Craig Venter Institute and the University of New South Wales in Sydney, Australia published the findings in the >Proceedings of the National Academy.