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The fine line between antibody yield and process throughput
31-Jul-2007 - UK researchers have developed a computer simulation to aid researchers find the optimum conditions for purifying polyclonal antibodies on affinity chromatography systems.
Don't trust 'Old Faithful' when pipetting hot liquids
26-Jul-2007 - Artel's extreme pipetting expedition team went to Yellowstone National Park, US, where they found that pipetting hot or cold liquids can cause delivery volume errors of up to 37 per cent.
Bio-Rad tackles the 'SELDI biomarker controversy'
24-Jul-2007 - Ever since Bio-Rad's acquisition of Ciphergen's SELDI MS (surface enhanced laser desorption/ionisation mass spectrometry) technology late last year, it has been fighting against the spectre of "controversial" research results obtained using the technology.
How flow rate can affect microfluidic cellular assays
23-Jul-2007 - UK researchers have shown that high fluid flow rates in microfluidic devices used for cellular assays can affect cell signalling channels and potentially interfere with drug screening results.
'Stretching' DNA could unravel drug interactions
17-Jul-2007 - US researchers have used atomic force microscopy (AFM) techniques to study the interactions within DNA strands as a first step to understanding how drugs interact with DNA.
Separating the DNA from the blood
12-Jul-2007 - US researchers have developed a microfluidic device for purifying and concentrating DNA directly from blood samples that could speed up the use of genomics in clinical trials.
AeonClad the way to better drug, particle and device coatings
12-Jul-2007 - University of Texas at Arlington (UTA) spin-out has exclusively licensed plasma coating technology that could improve the controlled release of drugs and the biocompatibility of medical implants.
The new 'gold' standard for predicting anticancer activity?
10-Jul-2007 - US researchers have designed an assay for determining the relative binding affinities of duplex and triplex binders that have potential use as anticancer agents and gene expression modifiers.
High-throughput peptide-cell adhesion array
04-Jul-2007 - US researchers have developed a high-throughput microfluidic array to aid help discover therapeutic and cell-targeting peptide agents by measuring the interactions between cells and peptides.
Immunoassays for the masses?
03-Jul-2007 - US researchers have developed a fast and efficient, label-free method of detecting the presence of antigens and disease biomarkers in clinical samples.
CellASIC's microfluidic tumour model
27-Jun-2007 - US microfluidics company CellASIC has developed a device that enables the effects of anticancer drugs to be studied in an environment that mimics a real cancerous growth.
New miRNA tumour supressors identified
25-Jun-2007 - Researchers have discovered three potential microRNA (miRNA) tumour suppressor genes using real-time PCR (polymerase chain reaction) techniques.
Faster gene mutations hold key to drug development
21-Jun-2007 - Scientists have developed a faster means of searching non-gene DNA for mutations that cause disease, paving the way for faster and cheaper drug development.
The sound of separation?
19-Jun-2007 - Swedish researchers have developed a method of separating a continuous flow of (bio)particles based on their size and density using acoustic forces.
Three-pronged approach identifies new cancer target
19-Jun-2007 - US researchers have developed a three part screening process to find new cancer genes and used it to identify a new gene associated with about a third of all breast cancers.
Melting DNA in microfluidic devices
13-Jun-2007 - German researchers have developed a microfluidic device that greatly increases the efficiency of measuring the melting temperature of DNA double strands.
Identifying the connections between cancer pathways
13-Jun-2007 - Researchers have used a protein lysate array to profile and classify multiple components of aberrant cell signalling pathways in 90 cancer cell lines.
The 'biogeneric' analysis problem
07-Jun-2007 - The apparent inability of current analytical techniques to fully characterise complex biological drugs still stands in the way of easy approval pathways for 'biogenerics' or copies of off-patent brand name biologics.
Nanodots take the matrix out of MALDI-MS
06-Jun-2007 - Japanese researchers have developed a way to increase protein sequence coverage by removing the need for organic matrices that can mask low weight analytes during MALDI-MS experiments.
High throughput screening of Alzheimer's inhibitors
04-Jun-2007 - Japanese researchers have developed a high throughput method for screening the activity of beta-amyloid protein aggregation inhibitors that should speed up the discovery of new Alzheimer's therapies.
Imaging the glutamate system
30-May-2007 - Researchers from the Karolinska Institutet in Stockholm, Sweden and AstraZeneca have developed the first method that allows the glutamate system to be studied in living people.
EpiStem's 'plucked hair' technology attracts AstraZeneca
23-May-2007 - A non-invasive technique that uses hair plucked from cancer patients to guide the development of new chemotherapy drugs has attracted the attention of UK pharma giant AstraZeneca.
Mechanisms of microRNA gene silencing revealed
17-May-2007 - Two new studies published this week have revealed how microRNA silences genes and prevents protein production, which could lead to new anticancer therapies.
New DNA damage test could reduce animal experiments
16-May-2007 - A new tool for checking if drugs damage DNA could reduce the number of animal experiments needed in drug development, and also be cheaper than conventional techniques, according to its designer.
New HIV tests look to speed up viral load analysis
15-May-2007 - Abbott Laboratories and Roche Diagnostics have both had HIV-1 tests approved by the US Food and Drug Administration (FDA) that should allow clinical laboratories to deliver viral load results faster.
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